The evaluation of potential toxicological effects of veterinary
pharmaceuticals and related products is required prior to product registration.
The safety evaluation of these products is performed in mammalian systems (including
the target species) for which extensive background data can be of great value
in the evaluation of responses observed in the studies. Huntingdon Life Sciences,
with over fifty years experience in this work is ideally placed to assist you
with this testing.
We have the capacity and a wide variety of the necessary skills,
enabling us to design and conduct all study types in accordance with the requirements
of the product under test. For example, all the common dosing routes, such as
dermal, inhalation and oral are available. In addition, where appropriate, for
some of the shorter-term studies, specialist routes of administration are available
such as vascular infusion and intrathecal. All areas of regulatory toxicology
can be covered:
- Rodent and Non-rodent toxicology
- Acute toxicity – single administration by intended therapeutic
route
- Repeat dose toxicity – target animal tolerance and long-term toxicity
assessment
- Carcinogenicity
- Reproductive toxicology
- Package in conventional toxicology species (required where residue in
human food is likely):
- Developmental toxicity in one rodent species; second species needed
if negative or equivocal result
- Two-generation reproduction study
Together with our extensive support departments, we provide the full comprehensive
package of tests required for registration and market authorisation, which ultimately
helps speed your product to market.
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