Radiolabelled test substances are essential for the study of their metabolism,
fate and degradation in animals, plants and environmental systems. For veterinary
pharmaceuticals 14C is often the isotope of choice but 3H, 35S, 125I and other isotopes are also used.
The use of test substances labelled with stable isotopes such as 2H, 13C and 15N can assist with the spectroscopic identification
of metabolites. They can also be used as internal standards in the analytical
methods employed in toxicokinetic studies.
The synthesis of isotopically-labelled compounds has been established as an
integral part of the Environmental Metabolism Department at Huntingdon Life
Sciences since 1970. The group has extensive experience in the synthesis of
radiolabelled veterinary products representing many different chemical classes.
Compounds are synthesised both for use in studies at Huntingdon Life Sciences
and as a custom synthesis service for supply directly to customers. Work in
the radiosynthesis section is performed to GLP standards and is regularly inspected
by QA.
All synthesised compounds undergo rigorous analytical characterisation and
QA audited certificates of analysis will be provided containing:
- Radiochemical Purity
- Chemical Purity
- Chemical Identity
- Specific Activity
Due to our close involvement with areas of research that make use of isotopically-labelled
compounds, we are strongly placed to offer consultancy and advice relating to
positioning of radioactive isotopes in a molecule and likely pathways of biotransformation.
We can also advise on the quantities of labelled compound required for all
types of study.
The synthesis of metabolite reference compounds is also undertaken.
Radiolabelled substances often degrade on storage more rapidly than the same
unlabelled substance. We can offer a fast turnaround repurification service
for any type of labelled compound, which includes the generation of a new analytical
data sheet.
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