The evaluation of potential toxicological effects of all pharmaceuticals is
required by various legislation around the world prior to product registration.
The safety evaluation of these products is performed in mammalian systems for
which extensive background data is required in order to accurately evaluate
any responses observed in the studies. Huntingdon Life Sciences, with over fifty
years experience in this work is ideally placed to assist you with this testing.
We have considerable experience, capacity and a wide variety of skills enabling
us to design and conduct all study types in accordance with the requirements
of the product under test. For example, all the common dosing routes, such as
dermal, inhalation, intravenous injection and oral are available as well as
some other specialist routes such as vascular infusion and intrathecal.
During carcinogenicity studies long-term toxicity is assessed over a 2 year
period with daily exposure. Rodents are commonly used for such studies, although
the use of large animals may be considered if justified.
Carcinogenicity bioassays are the longest and most expensive of the extensive
battery of toxicology studies required for the registration of pharmaceutical
products. Huntingdon Life Sciences has the substantial scientific and technical
resources and experience to deliver quality, regulatory-compliant rodent carcinogenicity
studies as well as the necessary ability to manage challenging requirements
and timelines.
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