Modern plant biotechnology can offer a way to quickly improve crop characteristics
such as yield, pest resistance or herbicide tolerance, often to a degree not
possible with traditional breeding methods. The new varieties are intended to
be identical to the original organism apart from the new traits. The safety
assessment is based upon an evaluation of the similarity to the traditional
variety.
The services we offer include:
- Ames test
- Mammalian cell mutation
- Micronucleus test
- Acute oral toxicity
- 90-day feeding study
- Chronic toxicity
- Carcinogenicity
- Reproductive toxicity
To evaluate the potential for allergenicity of the novel expressed protein,
a weight-of-evidence approach is taken. Physico-chemical aspects, including
heat stability, comparisons with known allergens, a history of allergenicity
of the donor or recipient organisms and degradability in the GI tract are the
main considerations.
- Protein digestion
- Oral allergenicity, measurement of total IgE.
- Safety and tolerance tests in target livestock species, for potential allergenicity,
intolerance and wholesomeness of the final product
- Aquatic
- Avian
- Ruminant
- Confirmation that the metabolism of pesticides is unchanged by the genetic
modification
- Transfer of antibiotic resistance markers
- Potential infectivity of viral vectors
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