At a relatively early stage of product development and before
many other studies can be carried out, basic and sometimes more complex, properties
of the test substance need to be known. These properties range from the physical
state of the material through to more complex tests, such as the determination
of the partition coefficient and dissociation constant of the active substance.
In addition to being essential to other studies, the data obtained
are required by regulatory authorities prior to the registration in order to
accurately characterise both the active substance and it's formulated crop protection
products. The information is also used to classify and label hazardous products
for handling, transport and any emergency procedures in case of accidental spillage.
Huntingdon Life Sciences offers a comprehensive product characterisation
service to the agrochemical industry with tests to satisfy national and international
guidelines and data requirements including:
- EU Directive 91/414 Annex II, (Active ingredient)
- EU Directive 91/414 Annex III, (Formulations)
- US EPA OPPTS 830 series, Active ingredients, Manufacturing-use products
and End-use products
- JMAFF 12-NohSan No 8147, Active ingredients
- OECD guidelines 101 – 123 inclusive
The advantages of using Huntingdon Life Sciences for your product characterisation
testing include:
- Versatile approach, individual tests or complete programmes can be undertaken
- Expert advice is available to design programmes to meet specific requirements.
- Our specialist scientific teams have extensive experience in performing
studies to meet EU, EPA and Japanese requirements
Product characterisation studies are performed with either pure or technical
grade active substances or formulations as appropriate and include:
- Storage stability and shelf-life, including accelerated storage test
- Analytical profile of batches (5 batch analysis)
- Melting point and boiling point
- Relative density or bulk density
- Vapour pressure and volatility
- Appearance
- Spectral data
- Solubility in water and organic solvents
- Octanol / water partition coefficient
- Stability in water, hydrolytic and photochemical degradation
- Dissociation constant
- Stability in air, photochemical degradation
- Flammability, autoflammability
- Flash point
- Explosive and oxidising properties
- Surface tension
- Acidity / alkalinity
- Viscosity, surface tension
- Various technical characteristics of formulations
- Physical and chemical compatibility of tank mixes
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