Most substances used in the crop protection industry are, by their
very nature, specifically toxic to one or more species. It is therefore vital
to assess the toxicity of such compounds in mammalian species and extrapolate
what effects, if any, are likely to occur in man following occupational, deliberate
or accidental exposure.
The evaluation of potential toxicological effects of all crop
protection products is required prior to product registration. The safety evaluation
of these products is performed in mammalian systems, for which extensive background
data can be of great value in the evaluation of responses observed in the studies.
Huntingdon Life Sciences, with over fifty years experience in this work is ideally
placed to assist you with this testing.
We have the capacity and a wide variety of the necessary skills,
enabling us to design and conduct all study types in accordance with the requirements
of the product under test. For example, all the common dosing routes, such as
dermal, inhalation and oral are available. In addition, where appropriate, for
some of the shorter-term studies, specialist routes of administration are available
such as vascular infusion and intrathecal. All areas of regulatory toxicology
can be covered:
- Rodent and non-rodent toxicology
- Acute toxicity – single administration by oral or dermal routes
- Repeat dose toxicity – daily administration by oral route for
28 days
- Reproductive toxicology: (normal package)
- Prenatal development toxicity in one rodent species and one non-rodent
species
- Two-generation reproduction study
- Developmental neurotoxicity study – may be required by regulators
for certain test substances
- Carcinogenicity
- Irritancy test
- Skin sensitization test - assessment of the potential to cause delayed
contact hypersensitivity: local lymph node assay.
Together with our extensive support departments, we provide
the full comprehensive package of tests required for registration and market
authorisation, which ultimately helps speed your product to market.
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