Assessing potential damage to genetic material is an integral part of the safety evaluation for all existing and new chemicals. A standard battery of assays is routinely used to examine various types of interaction with DNA. Huntingdon Life Sciences is a market leader in offering technical and scientific excellence in this area. Our work has been an integral part of international collaborations to develop the current regulatory framework.
- Gene mutation tests in bacteria (Ames) OECD 471 and mammalian cells (mouse lymphoma) OECD 476
- in vitro Chromosome aberration studies in human lymphocytes OECD 473
- in vivo Micronucleus formation in rodent erythrocytes OECD 474
- in vivo DNA repair (UDS) in rodent hepatocytes OECD 486
- in silico assessment using DEREK
- Mini-Ames
- Mitogenesis, cell cycling, apoptosis and cytotoxicity
- Aneuploidy assessment including fluorescence in situ hybridisation
- High-throughput testing with the SOS umuC bacterial reporter gene system
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