ADME and Dermal Penetration

Ecotoxicology

Environmental fate

Genetic Toxicology

Field trials

Mammalian Toxicology

Metabolite Identification

Physical Chemical Properties

Plant and Livestock Metabolism

Regulatory Affairs

Residue Analysis

Synthesis

In vitro Techniques

Programme Management and Consultancy

 

Environmental fate

Environmental fate studies are essential for both the environmental and human risk assessments of crop protection products. The data are used in computer models to predict the concentrations (PECs) of the active substances and their metabolites that may occur in the environment when the substance is used.

For risk assessment purposes, the environment is divided into compartments, the most important are soil, groundwater and surface water. Groundwater concentrations are of importance in assessing human exposure via drinking water, particularly in relation to the drinking water directive in the EU.

Environmental fate studies are conducted both in the laboratory, in model systems usually with radiolabelling, and in the field.

Environmental fate studies include:

  • Aerobic and anaerobic soil route (metabolism) and rate of degradation
  • Aerobic and anaerobic aquatic metabolism (water / sediment degradation)
  • Photodegradation in soil
  • Hydrolysis and photodegradation in water, including measurement of quantum yield
  • Field soil dissipation and accumulation (in the EU or USA)
  • Soil adsorption / desorption and column leaching
  • Field leaching and lysimeter
  • Degradation in the saturated zone
  • Identification of metabolites
  • Environmental modelling

We can offer to synthesise radiolabelled test substances that are usually needed for laboratory environmental fate studies.