ADME (absorption, distribution, metabolism and excretion) studies
can assist in the design of toxicology studies and are an important component
in the interpretation of the results of those studies and in the human risk
assessment. Recent regulatory initiatives, such as the draft revision of EU
91/414 currently under discussion in Europe, and in the USA and Europe the ILSI
/ HESI toxicological review, place increased emphasis on ADME studies and toxicokinetics.
Comparison of metabolites formed by rats with those formed in
livestock or plants is crucial in demonstrating that toxicology studies assess
the hazard from both active substances and their metabolites.
In vivo and in vitro dermal penetration studies
are critical to the specific risk assessments for operators, workers and bystanders
resulting from the use of crop protection products.
Studies offered include:
- ADME studies in the rat or other toxicological species if appropriate,
using oral or other routes of dosing as needed
- In vivo dermal penetration in the rat, rabbit and
minipig
- In vitro dermal penetration using animal and / or
human skin
We are actively involved in the dermal penetration working groups
in the EU (Skin Forum, EDETOX and CEFIC) and have presented and published our
work at various international meetings and in the scientific literature.
We can offer to synthesise radiolabelled test substances that
are usually needed for ADME studies and are often used for dermal penetration
studies.
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