Biocides

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Toxicology

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Toxicology Consultancy

 

Toxicology

The evaluation of potential toxicological effects of industrial chemicals is required prior to new product registration, or as necessary for existing product re-registration. Of particular interest are effects arising from accidental exposure to high concentrations and effects arising from long-term exposure to low concentrations in food and / or the environment. The safety evaluation of these products is performed in mammalian systems for which extensive background data can be of great value in the evaluation of responses observed in the studies. Huntingdon Life Sciences, with over fifty year’s experience in this work is ideally placed to assist you with this testing.

We have the capacity and a wide variety of the necessary skills, enabling us to design and conduct all study types in accordance with the requirements of the product under test. For example, all the common dosing routes, such as dermal, inhalation and oral are available. In addition, where appropriate, for some of the shorter-term studies, specialist routes of administration are available such as vascular infusion and intrathecal. All areas of regulatory toxicology can be covered:

  • Rodent and non-rodent toxicology
    • Acute toxicity – single administration by oral or dermal routes
    • Repeat dose toxicity – daily administration by oral route for 28 days
  • Irritancy test
  • Skin sensitization test - assessment of the potential to cause delayed contact hypersensitivity: local lymph node assay
  • Reproductive toxicology: (normal package)
    • Prenatal developmental toxicity in one rodent species and one non-rodent species
    • Two-generation reproduction study
  • Alternative screening protocols (used in the HPV program, for example)
    • Short-term reproduction/developmental screen (OECD protocol 421)
    • 4-week toxicity and reproduction / developmental screen (OECD protocol 422)
  • Developmental neurotoxicity study – may be required by regulators for certain chemicals

Together with our extensive support departments, we provide the full comprehensive package of tests required for registration and market authorisation, which ultimately helps speed your product to market.